XCOM takes place in the near future, as Washington, D.C. is shaken by several unusual and tragic incidents. A mysterious flu-like disease known as "Chryssalid" has swept across the region through local water sources, resulting in high-security locations being left understaffed as government workers are afflicted. Months after the initial outbreak, an alleged terrorist attack destroys part of the Washington Monument, and on September 11, a senator is killed by another terrorist cell reportedly disguised as members of her staff, greatly heightening local and national tensions. Most alarmingly, an assassination attempt on the President of the United States occurs only weeks after the previous attacks, carried out by the president's own Secret Service detail. In the midst of these events, XCOM agent Michael Ford must overcome the onslaught of the alien Sectoids and the humans under the Sectoids control, and defeat the masterminds behind the invasion.
The campaign storyline focuses on an alien invasion of Washington, D.C. in the near future. The alien race, known as the Sectoids, uses the eponymous portal-like Cyberdiscs to deploy their forces throughout the city. A shadow government organization called XCOM sends newly inducted agent Michael Ford into the area initially to disrupt a terrorist threat, but he quickly becomes embroiled in the fight to stop the invasion and save the capital from destruction. The online multiplayer feature of the game will support up to 12 players and includes several game modes such as "Free for All" and "Team Reaper."